Ro 5126766

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TargetMol
Product Code: TAR-T6971
Supplier: TargetMol
CodeSizePrice
TAR-T6971-1mg1mg£112.00
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TAR-T6971-2mg2mg£131.00
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TAR-T6971-5mg5mg£164.00
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TAR-T6971-1mL1 mL * 10 mM (in DMSO)£168.00
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Quantity:
TAR-T6971-10mg10mg£217.00
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Quantity:
TAR-T6971-25mg25mg£348.00
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Quantity:
TAR-T6971-50mg50mg£516.00
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TAR-T6971-100mg100mg£711.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.
CAS:
946128-88-7
Formula:
C21H18FN5O5S
Molecular Weight:
471.46
Pathway:
MAPK
Purity:
0.983
SMILES:
CNS(=O)(=O)Nc1nccc(Cc2c(C)c3ccc(Oc4ncccn4)cc3oc2=O)c1F
Target:
Raf; MEK

References

Ishii N, et al. Cancer Res. 2013, 73(13), 4050-4060. Wada M, et al. PLoS One. 2014, 9(11), e113217. Miller CR, et al. Gynecol Oncol. 2014, 133(1), 128-137.