GSK547

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TargetMol
Product Code: TAR-T7397
Supplier: TargetMol
CodeSizePrice
TAR-T7397-1mg1mg£103.00
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TAR-T7397-2mg2mg£117.00
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TAR-T7397-5mg5mg£148.00
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TAR-T7397-1mL1 mL * 10 mM (in DMSO)£149.00
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TAR-T7397-10mg10mg£195.00
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TAR-T7397-25mg25mg£301.00
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TAR-T7397-50mg50mg£436.00
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TAR-T7397-100mg100mg£570.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
GSK547 is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.
CAS:
2226735-55-1
Formula:
C20H18F2N6O
Molecular Weight:
396.402
Pathway:
NF-κb; Apoptosis
Purity:
0.98
SMILES:
Fc1cc(F)cc(c1)[C@@H]1CC=NN1C(=O)C1CCN(CC1)c1cc(ncn1)C#N
Target:
RIP kinase

References

RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer[J]. Cancer Cell, 2018, 34(5):757-774.e7.