YM976
Code | Size | Price |
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TAR-T7954-50mg | 50mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T7954-5mg | 5mg | £105.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T7954-1mL | 1 mL * 10 mM (in DMSO) | £114.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T7954-10mg | 10mg | £127.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T7954-25mg | 25mg | £164.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)
CAS:
191219-80-4
Formula:
C17H16ClN3O
Molecular Weight:
313.79
Pathway:
Metabolism
Purity:
0.9984
SMILES:
CCc1ccc2c(nc(=O)n(CC)c2n1)-c1cccc(Cl)c1
Target:
PDE
References
Aoki M , Yamamoto S , Kobayashi M , et al. Antiasthmatic effect of YM976, a novel PDE4 inhibitor, in guinea pigs[J]. Journal of Pharmacology and Experimental Therapeutics, 2001, 297(1):165-173.
Aoki M , Kobayashi M , Ishikawa J , et al. A Novel Phosphodiesterase Type 4 Inhibitor, YM976 (4-(3-Chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with Little Emetogenic Activity[J]. Journal of Pharmacology & Experimental Therapeutics, 2000, 295(1):255-260.