PFM01

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TargetMol
Product Code: TAR-T8880
Supplier: TargetMol
CodeSizePrice
TAR-T8880-5mg5mg£102.00
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Quantity:
TAR-T8880-1mL1 mL * 10 mM (in DMSO)£105.00
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Quantity:
TAR-T8880-10mg10mg£122.00
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Quantity:
TAR-T8880-25mg25mg£169.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T8880-50mg50mg£254.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T8880-100mg100mg£369.00
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Quantity:
TAR-T8880-200mg200mg£486.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
PFM01 is an inhibitor of MRE11 endonuclease. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR).
CAS:
1558598-41-6
Formula:
C14H15NO2S2
Molecular Weight:
293.4
Purity:
0.9976
SMILES:
CC(C)CN1C(=S)SC(=C/c2ccc(O)cc2)C1=O

References

Shibata A, et, al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014 Jan 9; 53(1): 7-18. V?lkening L, et, al. RAD50 regulates mitotic progression independent of DNA repair functions. FASEB J. 2020 Feb; 34(2): 2812-2820.