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TargetMol
Product Code: TAR-T9072
Supplier: TargetMol
CodeSizePrice
TAR-T9072-2mg2mg£98.00
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TAR-T9072-5mg5mg£115.00
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TAR-T9072-1mL1 mL * 10 mM (in DMSO)£125.00
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TAR-T9072-10mg10mg£148.00
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TAR-T9072-25mg25mg£230.00
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TAR-T9072-50mg50mg£369.00
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TAR-T9072-100mg100mg£515.00
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TAR-T9072-200mg200mg£707.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively). BDTX-189 exhibits anticancer activity.
CAS:
2414572-47-5
Formula:
C29H29ClN6O4
Molecular Weight:
561.04
Pathway:
Tyrosine Kinase/Adaptors; NF-κb; Apoptosis; JAK/STAT signaling; Angiogenesis
Purity:
0.9886
SMILES:
Clc1cc(Nc2ncnc3cc(OCCN4CCOCC4)c(NC(=O)C=C)cc23)ccc1OCc1ccccn1
Target:
EGFR; HER; BTK; RIP kinase

References

Elizabeth Buck, et al. BDTX-189, a Potent and Selective Inhibitor of Allosteric EGFR and HER2 Oncogenic Mutations.