HQ461

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TargetMol
Product Code: TAR-T9849
Supplier: TargetMol
CodeSizePrice
TAR-T9849-1mg1mg£101.00
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TAR-T9849-2mg2mg£114.00
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TAR-T9849-5mg5mg£142.00
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TAR-T9849-1mL1 mL * 10 mM (in DMSO)£148.00
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Quantity:
TAR-T9849-10mg10mg£195.00
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Quantity:
TAR-T9849-25mg25mg£356.00
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Quantity:
TAR-T9849-50mg50mg£550.00
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Quantity:
TAR-T9849-100mg100mg£755.00
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Quantity:
TAR-T9849-500mg500mg£1,460.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.
CAS:
1226443-41-9
Formula:
C15H15N5OS2
Molecular Weight:
345.44
Pathway:
Cell Cycle/Checkpoint
Purity:
0.98
SMILES:
Cc1cnc(NC(=O)Cc2csc(Nc3cccc(C)n3)n2)s1
Target:
CDK

References

Lv L, et al. Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation. Elife. 2020 Aug 17;9:e59994.