EX229

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TargetMol
Product Code: TAR-TQ0028
Supplier: TargetMol
CodeSizePrice
TAR-TQ0028-1mg1mg£95.00
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TAR-TQ0028-2mg2mg£106.00
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TAR-TQ0028-5mg5mg£125.00
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TAR-TQ0028-1mL1 mL * 10 mM (in DMSO)£132.00
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TAR-TQ0028-10mg10mg£161.00
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TAR-TQ0028-25mg25mg£258.00
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TAR-TQ0028-50mg50mg£389.00
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TAR-TQ0028-100mg100mg£548.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
EX229 is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.
CAS:
1219739-36-2
Formula:
C24H18ClN3O3
Molecular Weight:
431.88
Pathway:
Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
Purity:
0.9936
SMILES:
Cc1ccc(Oc2nc3cc(c(Cl)cc3[nH]2)-c2ccc3n(C)ccc3c2)cc1C(O)=O
Target:
AMPK

References

Bultot L, et al. Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle. Am J Physiol Endocrinol Metab. 2016 Oct 1;311(4):E706-E719. Xiao B, et al. Structural basis of AMPK regulation by small molecule activators. Nat Commun. 2013;4:3017.