KIRA6

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TargetMol
Product Code: TAR-TQ0076
Supplier: TargetMol
CodeSizePrice
TAR-TQ0076-1mg1mg£102.00
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TAR-TQ0076-2mg2mg£114.00
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TAR-TQ0076-5mg5mg£144.00
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TAR-TQ0076-1mL1 mL * 10 mM (in DMSO)£158.00
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TAR-TQ0076-10mg10mg£183.00
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TAR-TQ0076-25mg25mg£300.00
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TAR-TQ0076-50mg50mg£402.00
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TAR-TQ0076-100mg100mg£564.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
KIRA6 is an effective inhibitor of IRE1α RNase kinase (IC50: 0.6 μM). It can trigger an apoptotic response.
CAS:
1589527-65-0
Formula:
C28H25F3N6O
Molecular Weight:
518.544
Pathway:
Cell Cycle/Checkpoint
Purity:
1
SMILES:
CC(C)(C)c1nc(-c2ccc(NC(=O)Nc3cccc(c3)C(F)(F)F)c3ccccc23)c2c(N)nccn12
Target:
IRE1

References

Mahameed M,et al. The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors. Cell Death Dis. 2019 Apr 1;10(4):300. Ghosh R, et al. Allosteric inhibition of the IRE1? RNase preserves cell viability and function during endoplasmic reticulum stress. Cell. 2014 Jul 31;158(3):534-48. Wang J, Zhang J, Guo Z, et al.Targeting HSP70 chaperones by rhein sensitizes liver cancer to artemisinin derivatives.Phytomedicine.2023: 155156.