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TargetMol
Product Code: TAR-TQ0127
Supplier: TargetMol
CodeSizePrice
TAR-TQ0127-1mg1mg£124.00
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TAR-TQ0127-2mg2mg£147.00
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TAR-TQ0127-5mg5mg£189.00
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TAR-TQ0127-1mL1 mL * 10 mM (in DMSO)£222.00
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TAR-TQ0127-10mg10mg£254.00
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TAR-TQ0127-25mg25mg£442.00
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TAR-TQ0127-50mg50mg£619.00
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TAR-TQ0127-100mg100mg£852.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
AMG 232 is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.
CAS:
1352066-68-2
Formula:
C28H35Cl2NO5S
Molecular Weight:
568.55
Pathway:
Ubiquitination; Apoptosis
Purity:
0.9886
SMILES:
CC(C)[C@@H](CS(C(C)C)(=O)=O)N([C@@H]([C@H](C[C@]1(C)CC(O)=O)c2cccc(Cl)c2)c(cc2)ccc2Cl)C1=O
Target:
Mdm2; E1/E2/E3 Enzyme

References

Canon J, et al. The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents. Mol Cancer Ther. 2015 Mar;14(3):649-58. Rew Y, et al. Discovery of a small molecule MDM2 inhibitor (AMG 232) for treating cancer. J Med Chem. 2014 Aug 14;57(15):6332-41.