TargetMol

Azaserine

Product Code:
 
TAR-TQ0158
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0158-2mg2mg£111.00
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Further Information

Bioactivity:
Azaserine is a tumor-inhibiting antibiotic isolated from a species of Streptomyces and functions as an inhibitor of glutamine amidotransferase.
CAS:
115-02-6
Formula:
C5H7N3O4
Molecular Weight:
173.128
Pathway:
Microbiology/Virology;
Purity:
0.98
SMILES:
N[C@@H](COC(=O)C=[N+]=[N-])C(O)=O
Target:
Antibiotic

References

Wise DR, et al. Glutamine addiction: a new therapeutic target in cancer. Trends Biochem Sci. 2010 Aug;35(8):427-33. Lyons SD, et al. Cytotoxic mechanisms of glutamine antagonists in mouse L1210 leukemia. J Biol Chem. 1990 Jul 5;265(19):11377-81. Rajapakse AG, et al. The hexosamine biosynthesis inhibitor azaserine prevents endothelial inflammation and dysfunction under hyperglycemic condition through antioxidant effects. Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H815-22.