ONO-AE3-208

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TargetMol
Product Code: TAR-TQ0290
Supplier: TargetMol
CodeSizePrice
TAR-TQ0290-1mg1mg£103.00
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TAR-TQ0290-2mg2mg£118.00
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TAR-TQ0290-5mg5mg£148.00
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TAR-TQ0290-1mL1 mL * 10 mM (in DMSO)£156.00
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TAR-TQ0290-10mg10mg£195.00
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TAR-TQ0290-25mg25mg£283.00
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TAR-TQ0290-50mg50mg£385.00
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TAR-TQ0290-100mg100mg£539.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
ONO-AE3-208 is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer.
CAS:
402473-54-5
Formula:
C24H21FN2O3
Molecular Weight:
404.441
Pathway:
Immunology/Inflammation; GPCR/G Protein
Purity:
0.9804
SMILES:
CC(C(=O)Nc1cc(ccc1CCCC(O)=O)C#N)c1ccc(F)c2ccccc12
Target:
Prostaglandin Receptor

References

Xu S, et al. An EP4 Antagonist ONO-AE3-208 Suppresses Cell Invasion, Migration, and Metastasis of Prostate Cancer. Cell Biochem Biophys. 2014 Apr 18. Xu S, et al. Inhibitory effect of ONO-AE3-208 on the formation of bone metastasis of prostate cancer in mice. Zhonghua Nan Ke Xue. 2014 Aug;20(8):684-9. Ren Y, et al. Prostaglandin E2 mediates connecting tubule glomerular feedback. Hypertension. 2013 Dec;62(6):1123-8.