(R)-10,11-Dehydrocurvularin
| Code | Size | Price |
|---|
| TAR-T10034-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
10,11-Dehydrocurvularin is an antibiotic and a strong activator of the heat shock response. It inhibits the TGF-β signaling pathway and has anti-tumorous activity.
CAS:
1095588-70-7
Formula:
C16H18O5
Molecular Weight:
290.315
Purity:
0.98
SMILES:
C[C@@H]1CCCC=CC(=O)c2c(O)cc(O)cc2CC(=O)O1
References
1. Xu Y, et al. Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus. Appl Environ Microbiol. 2013 Mar;79(6):2038-47.
2. Cochrane RV, et al. Comparison of 10,11-Dehydrocurvularin Polyketide Synthases from Alternaria cinerariae and Aspergillus terreus Highlights Key Structural Motifs. Chembiochem. 2015 Nov;16(17):2479-83.