TargetMol

Abemaciclib metabolite M2

Product Code:
 
TAR-T10220
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10220-5mg5mg£170.00
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TAR-T10220-10mg10mg£229.00
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Further Information

Bioactivity:
Abemaciclib Metabolites M2 is a metabolite of abemaciclib, acts as a potent CDK4 and CDK6 inhibitor (IC50s: 1-3 nM) with anti-cancer activity.
CAS:
1231930-57-6
Formula:
C25H28F2N8
Molecular Weight:
478.552
Pathway:
Cell Cycle/Checkpoint
Purity:
0.98
SMILES:
CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc(CN3CCNCC3)cn2)ncc1F
Target:
CDK

References

1. Teresa Burke, et al. Abstract 2830: The major human metabolites of abemaciclib are inhibitors of CDK4 and CDK6. Cancer Research. July 2016, 76 (14).