Abemaciclib metabolite M2

TargetMol
Product Code: TAR-T10220
Supplier: TargetMol
CodeSizePrice
TAR-T10220-5mg5mg£170.00
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TAR-T10220-10mg10mg£229.00
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Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Further Information

Bioactivity:
Abemaciclib Metabolites M2 is a metabolite of abemaciclib, acts as a potent CDK4 and CDK6 inhibitor (IC50s: 1-3 nM) with anti-cancer activity.
CAS:
1231930-57-6
Formula:
C25H28F2N8
Molecular Weight:
478.552
Pathway:
Cell Cycle/Checkpoint
Purity:
0.98
SMILES:
CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc(CN3CCNCC3)cn2)ncc1F
Target:
CDK

References

1. Teresa Burke, et al. Abstract 2830: The major human metabolites of abemaciclib are inhibitors of CDK4 and CDK6. Cancer Research. July 2016, 76 (14).