AMG8380
| Code | Size | Price |
|---|
| TAR-T10301-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
AMG8380 is an orally active and less active enantiomer of AMG8379 served as a negative control. AMG8380 inhibits human and mouse voltage-gated sodium channel NaV1.7 (IC50s: 0.907 and 0.387 μM). AMG8380 blocks Tetrodotoxin (TTX)-sensitive native channels (IC50: 2560 nM).
CAS:
1642112-32-0
Formula:
C25H16ClF2N3O5S
Molecular Weight:
543.93
Purity:
0.98
SMILES:
O=S(NC1=NOC=C1)(C2=CC(C=CC(N3C4=CC(F)=C(C=C4OC)C5=CC(Cl)=CC(F)=C5)=O)=C3C=C2)=O.[R]
References
1. Kornecook TJ, et al. Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel NaV1.7. J Pharmacol Exp Ther. 2017 Jul;362(1):146-160.