Fludarabine

TargetMol
Product Code: TAR-T1038
Supplier: TargetMol
CodeSizePrice
TAR-T1038-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T1038-5mg5mg£111.00
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Quantity:
TAR-T1038-10mg10mg£112.00
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TAR-T1038-25mg25mg£135.00
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TAR-T1038-50mg50mg£151.00
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TAR-T1038-100mg100mg£184.00
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TAR-T1038-200mg200mg£229.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Further Information

Bioactivity:
Fludarabine is a nucleic acid synthesis Inhibitor and a STAT1 activation inhibitor.
CAS:
21679-14-1
Formula:
C10H12FN5O4
Molecular Weight:
285.235
Pathway:
JAK/STAT signaling; Apoptosis; Stem Cells; DNA Damage/DNA Repair; Cell Cycle/Checkpoint
Purity:
0.9988
SMILES:
Nc1nc(F)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O
Target:
Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; STAT

References

1. Meng H, et al. Antitumor activity of fludarabine against human multiple myeloma in vitro and in vivo. Eur J Haematol. 2007 Dec;79(6):486-93. 2. Torella D, et al. Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation. Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2935-43. 3. Bellosillo B, et al. In vitro evaluation of fludarabine in combination with cyclophosphamide and/or mitoxantrone in B-cell chronic lymphocytic leukemia. Blood. 1999 Oct 15;94(8):2836-43. 4. Zhu Y, Gu H, Yang L, et al. The sequential role of Mst1/mTORC1/STAT1 activity in chemokine receptor 2-regulated B cell receptor signaling[J]. Authorea Preprints. 2021 5. Wang S, He F, Li Z, et al. Long non-coding RNA BANCR promotes interferon-?-induced cardiomyocyte apoptosis by targeting signal transducer and activator of transcription 1 in vitro[J]. International Journal of Clinical and Experimental Pathology. 2020, 13(11): 2840. 6. Chu K H, Lin S Y, Chiang B L. STAT6 Pathway Is Critical for the Induction and Function of Regulatory T Cells Induced by Mucosal B Cells[J]. Frontiers in immunology. 2020, 11. 7. Chen C, Lu M, Lin S, et al. The nuclear gene rpl18 regulates erythroid maturation via JAK2-STAT3 signaling in zebrafish model of Diamond?Blackfan anemia[J]. Cell Death & Disease. 2020, 11(2): 1-11. 8. Yang L, Li N, Yang D, et al. CCL2 regulation of MST1-mTOR-STAT1 signaling axis controls BCR signaling and B-cell differentiation[J]. Cell Death & Differentiation. 2021: 1-18.