BI 653048
| Code | Size | Price |
|---|
| TAR-T10535-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
BI 653048 is a selective and orally active agonist of nonsteroidal glucocorticoid (IC50: 55 nM). BI 653048 is also an HCV NS3 protease inhibitor.
CAS:
1198784-72-3
Formula:
C23H25F4N3O4S
Molecular Weight:
515.52
Pathway:
Metabolism
Purity:
0.98
SMILES:
CCS(=O)(=O)c1cc2cc(C[C@](O)(CC(C)(C)c3ccc(F)cc3C(N)=O)C(F)(F)F)[nH]c2cn1
Target:
P45
References
1. Reeves JT, et al. Development of a large scale asymmetric synthesis of the glucocorticoid agonist BI 653048 BS H3PO4.J Org Chem. 2013 Apr 19;78(8):3616-35.
2. Harcken C, et al. Optimization?of?drug-like?properties?of?nonsteroidal?glucocorticoid?mimetics?and?identification?of a?clinical?candidate.ACS Med Chem Lett.?2014 Nov 20;5(12):1318-23.
3. Montse Llinas-Brunet, et al. Latest bibliographic data on file with the International Bureau