BI 653048 phosphate
| Code | Size | Price |
|---|
| TAR-T10535L-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
BI 653048 phosphate is a selective and orally active agonist of nonsteroidal glucocorticoid (GC)(IC50 : 55 nM).
CAS:
1198784-97-2
Formula:
C23H28F4N3O8PS
Molecular Weight:
613.52
Pathway:
Metabolism
Purity:
0.98
SMILES:
OP(O)(O)=O.CCS(=O)(=O)c1cc2cc(C[C@](O)(CC(C)(C)c3ccc(F)cc3C(N)=O)C(F)(F)F)[nH]c2cn1
Target:
P45
References
1. Reeves JT, et al. Development of a large scale asymmetric synthesis of the glucocorticoid agonist BI 653048 BS H3PO4.J Org Chem. 2013 Apr 19;78(8):3616-35.
2. Harcken C, et al. Optimization?of?drug-like?properties?of?nonsteroidal?glucocorticoid?mimetics?and?identification?of a?clinical?candidate.ACS Med Chem Lett.?2014 Nov 20;5(12):1318-23.
3. Montse Llinas-Brunet, et al. Latest bibliographic data on file with the International Bureau