Mezigdomide

Contact us
TargetMol
Product Code: TAR-T10703
Supplier: TargetMol
CodeSizePrice
TAR-T10703-1mg1mg£165.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T10703-5mg5mg£302.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T10703-10mg10mg£438.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T10703-25mg25mg£675.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T10703-50mg50mg£922.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T10703-100mg100mg£1,219.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T10703-500mg500mg£2,368.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

1 / 1
❮❯

Documents

Further Information

Bioactivity:
CC-92480 is a cereblon E3 ubiquitin ligase modulating drug (CELMoD) with potent antimyeloma activity.
CAS:
2259648-80-9
Formula:
C32H30FN5O4
Long Description:
Mezigdomide, alias CC-92480, is a novel and selective CRBN E3 ubiquitin ligase modulator. It functions in the form of a molecular glue to recruit IKZF1 and ZFP91 targets to the CRL4CRBN E3 ubiquitin ligase, leading to their ubiquitination and degradation.
Molecular Weight:
567.621
Pathway:
Apoptosis; Ubiquitination
Purity:
0.9721
SMILES:
Fc1cc(ccc1N1CCN(Cc2ccc(COc3cccc4C(=O)N(Cc34)[C@H]3CCC(=O)NC3=O)cc2)CC1)C#N
Target:
Apoptosis; E1/E2/E3 Enzyme

References

1. Nooka AK, et al. Mechanism of Action and Novel IMiD-Based Compounds and Combinations in Multiple Myeloma. Cancer J. 2019 Jan/Feb;25(1):19-31.