TargetMol

CSRM617

Product Code:
 
TAR-T10896
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10896-5mg5mg£850.00
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Quantity:
TAR-T10896-50mg50mg£1,661.00
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Quantity:
TAR-T10896-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
CSRM617 is a selective small molecule inhibitor of the transcription factor ONECUT2 (OC2, the main regulator of androgen receptor). The Kd in SPR analysis is 7.43 uM, which can directly bind to the OC2-HOX domain. CSRM617 induces apoptosis by cleaving the presence of Caspase-3 and PARP. CSRM617 is well tolerated in a mouse model of prostate cancer.
CAS:
787504-88-5
Formula:
C10H13N3O5
Molecular Weight:
255.23
Purity:
0.98
SMILES:
N[C@@H](CO)C(=O)NN=Cc1ccc(O)c(O)c1O

References

1. Rotinen M, et al. ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis. Nat Med. 2018 Dec;24(12):1887-1898.