CSRM617

TargetMol
Product Code: TAR-T10896
Supplier: TargetMol
CodeSizePrice
TAR-T10896-5mg5mg£850.00
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Quantity:
TAR-T10896-50mg50mg£1,661.00
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Quantity:
TAR-T10896-100mg100mg£2,079.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Further Information

Bioactivity:
CSRM617 is a selective small molecule inhibitor of the transcription factor ONECUT2 (OC2, the main regulator of androgen receptor). The Kd in SPR analysis is 7.43 uM, which can directly bind to the OC2-HOX domain. CSRM617 induces apoptosis by cleaving the presence of Caspase-3 and PARP. CSRM617 is well tolerated in a mouse model of prostate cancer.
CAS:
787504-88-5
Formula:
C10H13N3O5
Molecular Weight:
255.23
Purity:
0.98
SMILES:
N[C@@H](CO)C(=O)NN=Cc1ccc(O)c(O)c1O

References

1. Rotinen M, et al. ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis. Nat Med. 2018 Dec;24(12):1887-1898.