TargetMol

DMAPT

Product Code:
 
TAR-T11060
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T11060-25mg25mgEnquire
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TAR-T11060-1mL1 mL * 10 mM (in DMSO)£112.00
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TAR-T11060-10mg10mg£140.00
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Further Information

Bioactivity:
DMAPT is a water-soluble analogue of Parthenolide (PTL). It is an orally active NF-κB inhibitor with an LD50 of 1.7 μM on primary acute myeloid leukemia cells.
CAS:
870677-05-7
Formula:
C17H27NO3
Molecular Weight:
293.407
Pathway:
NF-κb
Purity:
0.9843
SMILES:
[H][C@@]12CCC(C)=C/CC[C@@]3(C)O[C@@H]3[C@@]1([H])OC(=O)[C@@H]2CN(C)C
Target:
NF-κB

References

1. Neelakantan S, et al. Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-kappaB inhibitor, DMAPT (LC-1). Bioorg Med Chem Lett. 2009 Aug 1;19(15):4346-9. 2. Mendonca MS, et al. DMAPT inhibits NF-?B activity and increases sensitivity of prostate cancer cells to X-rays in vitro and in tumor xenografts in vivo. Free Radic Biol Med. 2017 Nov;112:318-326. 3. Morel KL, et al. Chronic low dose ethanol induces an aggressive metastatic phenotype in TRAMP mice, which is counteracted by parthenolide. Clin Exp Metastasis. 2018 Oct;35(7):649-661.