FR 167653
| Code | Size | Price |
|---|
| TAR-T11327-5mg | 5mg | £483.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
FR 167653 (FR 167653 sulfate) is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo. FR 167653 , an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity.
CAS:
158876-66-5
Formula:
C24H20FN5O6S
Molecular Weight:
525.51
Pathway:
MAPK
Purity:
0.98
SMILES:
OS(O)(=O)=O.Fc1ccc(cc1)-c1nn2CCN(Nc2c1-c1ccncc1)C(=O)C(=O)c1ccccc1
Target:
p38 MAPK
References
1. Furuichi K, et al. Administration of FR167653, a new anti-inflammatory compound, prevents renal ischaemia/reperfusion injury in mice. Nephrol Dial Transplant. 2002 Mar;17(3):399-407.
2. Iwata Y, et al. p38 Mitogen-activated protein kinase contributes to autoimmune renal injury in MRL-Fas lpr mice. J Am Soc Nephrol. 2003 Jan;14(1):57-67.
3. Kawashima Y, et al. FR167653 attenuates ischemia and reperfusion injury of the rat lung with suppressing p38mitogen-activated protein kinase. J Heart Lung Transplant. 2001 May;20(5):568-74.