Gln-AMS TFA (209543-57-7 free base)

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TargetMol
Product Code: TAR-T11403L
Supplier: TargetMol
CodeSizePrice
TAR-T11403L-200mg200mgEnquire
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TAR-T11403L-500mg500mgEnquire
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TAR-T11403L-5mg5mg£461.00
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TAR-T11403L-1mL1 mL * 10 mM (in DMSO)£576.00
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TAR-T11403L-10mg10mg£673.00
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TAR-T11403L-25mg25mg£1,309.00
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TAR-T11403L-50mg50mg£2,015.00
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TAR-T11403L-100mg100mg£2,862.00
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Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Gln-AMS(TFA) inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM. Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor.
CAS:
T11403L
Formula:
C17H23F3N8O10S
Molecular Weight:
588.47
Purity:
0.98
SMILES:
O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@H]3COS(=O)(NC([C@@H](N)CCC(N)=O)=O)=O.OC(C(F)(F)F)=O

References

1. Rath VL, et al. How glutaminyl-tRNA synthetase selects glutamine. Structure. 1998 Apr 15;6(4):439-49. 2. Fang P, et al. Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase. Nat Commun. 2015 Mar 31;6:6402.