TargetMol

GNA002

Product Code:
 
TAR-T11436
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11436-5mg5mg£704.00
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Further Information

Bioactivity:
GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).
CAS:
1385035-79-9
Formula:
C42H55NO8
Molecular Weight:
701.901
Pathway:
Chromatin/Epigenetic
Purity:
0.98
SMILES:
[H][C@@]12C[C@@]3([H])C=C4C(=O)c5c(O)c(CC=C(/C)CCC=C(C)C)c(O)c(CC=C(C)C)c5O[C@@]14[C@@](CC=C(C)C(=O)NCCOCC)(OC2(C)C)C3=O
Target:
Histone Methyltransferase

References

1. Wang X, et al. A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination. EMBO J. 2017 May, 36(9):1243-1260.