TargetMol

Obtusifoliol

Product Code:
 
TAR-T12286
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T12286-5mg5mgEnquire
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Further Information

Bioactivity:
Obtusifoliol is a specific inhibitor of CYP51(Trypanosoma brucei (TB) and human CYP51 with Kd values of 1.2 μM and 1.4 μM, respectively).
CAS:
16910-32-0
Formula:
C30H50O
Molecular Weight:
426.729
Purity:
0.98
SMILES:
[H][C@@]12CCC3=C(CC[C@]4(C)[C@H](CC[C@@]34C)[C@H](C)CCC(=C)C(C)C)[C@@]1(C)CC[C@H](O)[C@H]2C

References

1. Lepesheva GI, et al. CYP51 from Trypanosoma brucei is obtusifoliol-specific.Biochemistry. 2004 Aug 24;43(33):10789-99. 2. Aghaei M, et al Obtusifoliol?related?steroids?from?Euphorbia?sogdiana?with?cell?growth?inhibitory?activity?and?apoptotic?effects?on?breast?cancer?cells?(MCF-7?and?MDA-MB231). Steroids.?2016 Nov;115:90-97. doi: 10.1016/j.steroids.2016.07.008. Epub 2016 Jul 26.