PNZ5

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TargetMol
Product Code: TAR-T12513
Supplier: TargetMol
CodeSizePrice
TAR-T12513-1mg1mg£227.00
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TAR-T12513-2mg2mg£306.00
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TAR-T12513-1mL1 mL * 10 mM (in DMSO)£426.00
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TAR-T12513-5mg5mg£431.00
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Quantity:
TAR-T12513-10mg10mg£600.00
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Quantity:
TAR-T12513-25mg25mg£863.00
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Quantity:
TAR-T12513-50mg50mg£1,187.00
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Quantity:
TAR-T12513-100mg100mg£1,581.00
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Quantity:
TAR-T12513-500mg500mg£3,107.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
PNZ5 is a potent and isoxazole-based pan-BET inhibitor, with high selectivity and potency similar to the well-established (+)-JQ1, with a KD of 5.43 nM for BRD4(1).
CAS:
1629277-36-6
Formula:
C20H18N2O2
Molecular Weight:
318.37
Pathway:
Chromatin/Epigenetic
Purity:
0.9953
SMILES:
CN1[C@H](C=2C(C1=O)=CC=C(C2)C=3C(C)=NOC3C)C4=CC=CC=C4
Target:
Epigenetic Reader Domain

References

Montenegro RC, et al. BET inhibition as a new strategy for the treatment of gastric cancer. Oncotarget. 2016 Jul 12;7(28):43997-44012.