Solabegron HCl
| Code | Size | Price |
|---|
| TAR-T12970L-5mg | 5mg | £930.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T12970L-50mg | 50mg | £1,821.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T12970L-100mg | 100mg | £2,319.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Solabegron (GW-427,353), is a selective agonist of β3 adrenergic receptors. In addition, Solabegron has been shown to produce visceral analgesia by releasing somatostatin from fat cells.
CAS:
451470-34-1
Formula:
C23H24Cl2N2O3
Molecular Weight:
447.36
Purity:
0.98
SMILES:
Cl.O[C@@H](CNCCNc1cccc(c1)-c1cccc(c1)C(O)=O)c1cccc(Cl)c1
References
1. Rosa GM, Ferrero S, Nitti VW, Wagg A, Saleem T, Chapple CR. Cardiovascular Safety of ?(3)-adrenoceptor Agonists for the Treatment of Patients with Overactive Bladder Syndrome. Eur Urol. 2015 Sep 28. pii: S0302-2838(15)00864-7. doi: 10.1016/j.eururo.2015.09.007. [Epub ahead of print] Review. PubMed PMID: 26422675.
2. Thiagamoorthy G, Giarenis I, Cardozo L. Early investigational ?3 adreno-receptor agonists for the management of the overactive bladder syndrome. Expert Opin Investig Drugs. 2015;24(10):1299-306. doi: 10.1517/13543784.2015.1076390. Epub 2015 Aug 14. PubMed PMID: 26292923.
3. Hertzberg R, Monreal Santiago G, Moberg C. Synthesis of the ?3-adrenergic receptor agonist solabegron and analogous N-(2-ethylamino)-?-amino alcohols from O-acylated cyanohydrins - expanding the scope of minor enantiomer recycling. J Org Chem. 2015 Mar 6;80(5):2937-41. doi: 10.1021/acs.joc.5b00322. Epub 2015 Feb 24. PubMed PMID: 25689345.
4. Ellsworth P, Fantasia J. Solabegron: a potential future addition to the ?-3 adrenoceptor agonist armamentarium for the management of overactive bladder. Expert Opin Investig Drugs. 2015 Mar;24(3):413-9. doi: 10.1517/13543784.2015.1001836. Epub 2015 Jan 5. Review. PubMed PMID: 25557359.