TargetMol

TAK-828F

Product Code:
 
TAR-T13067
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13067-5mg5mg£1,733.00
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Quantity:
TAR-T13067-50mg50mg£3,428.00
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Quantity:
TAR-T13067-100mg100mg£4,729.00
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This product comes from: United States.
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Further Information

Bioactivity:
TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (IC50=1.9 nM, reporter gene IC50=6.1 nM).
CAS:
1854901-94-2
Formula:
C28H32FN3O5
Molecular Weight:
509.578
Pathway:
Metabolism
Purity:
0.98
SMILES:
COc1ccc2[C@@H](N(CCc2n1)C(=O)[C@@H]1C[C@H](CC(O)=O)C1)C(=O)Nc1cc2CCC(C)(C)c2c(F)c1
Target:
ROR

References

1. Kono M, et al. Discovery of [ cis-3-({(5 R)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1 H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5 H)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor ?t Inverse Agonist. J Med Chem. 2018 Apr 12;61(7):2973-2988.