T-705RTP sodium
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Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
T-705RTP sodium is a selective and GTP-competitive of influenza virus RNA polymerase(IC50 of 0.14 μM and a Ki of 1.52 μM), has potent anti-influenza virus activity.
CAS:
356783-10-3
Formula:
C10H12FN3Na3O15P3
Molecular Weight:
595.101
Purity:
0.98
SMILES:
NC(=O)c1nc(F)cn([C@@H]2O[C@H](COP(=O)(O[Na])OP(=O)(O[Na])OP(O)(=O)O[Na])[C@@H](O)[C@H]2O)c1=O
References
1. Furuta Y, et al. Mechanism of action of T-705 against influenza virus. Antimicrob Agents Chemother. 2005 Mar;49(3):981-6.
2. Sangawa H, et al. Mechanism of action of T-705 ribosyl triphosphate against influenza virus RNA polymerase. Antimicrob Agents Chemother. 2013 Nov;57(11):5202-8.