TargetMol

(+)-Apogossypol

Product Code:
 
TAR-T13459
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13459-5mg5mg£1,010.00
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TAR-T13459-50mg50mg£1,982.00
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Quantity:
TAR-T13459-100mg100mg£2,560.00
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This product comes from: United States.
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Further Information

Bioactivity:
(+)-Apogossypol is an antagonist of pan-BCL-2. (+)-Apogossypol binds to Mcl-1(Bcl-2 and Bcl-xL with EC50s of 2.6, 2.8 and 3.69 μM, respectively).
CAS:
66389-74-0
Formula:
C28H30O6S
Molecular Weight:
494.6
Purity:
0.98
SMILES:
OC1=C2C=C(O)C(O)=C(C(C)C)C2=CC(C)=[C@]1[C@]3=C(C)C=C4C(C(C)C)=C(O)C(O)=CC4=C3O.[S]

References

1. Wei J, et al. Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins. Mol Cancer Ther. 2009 Apr;8(4):904-13. 2. Zhan W, et al. Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo. Mol Med Rep. 2015 Jun;11(6):4142-8.