(+)-Apogossypol

TargetMol
Product Code: TAR-T13459
Supplier: TargetMol
CodeSizePrice
TAR-T13459-5mg5mg£1,010.00
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Quantity:
TAR-T13459-50mg50mg£1,982.00
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Quantity:
TAR-T13459-100mg100mg£2,560.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Further Information

Bioactivity:
(+)-Apogossypol is an antagonist of pan-BCL-2. (+)-Apogossypol binds to Mcl-1(Bcl-2 and Bcl-xL with EC50s of 2.6, 2.8 and 3.69 μM, respectively).
CAS:
66389-74-0
Formula:
C28H30O6S
Molecular Weight:
494.6
Purity:
0.98
SMILES:
OC1=C2C=C(O)C(O)=C(C(C)C)C2=CC(C)=[C@]1[C@]3=C(C)C=C4C(C(C)C)=C(O)C(O)=CC4=C3O.[S]

References

1. Wei J, et al. Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins. Mol Cancer Ther. 2009 Apr;8(4):904-13. 2. Zhan W, et al. Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo. Mol Med Rep. 2015 Jun;11(6):4142-8.