Maytansinoid DM4
| Code | Size | Price |
|---|
| TAR-T13766-5mg | 5mg | £4,890.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Maytansinoid DM4 can be used as a cytotoxic moiety of ADC. Maytansinoid DM4 is a thiol-containing maytansine derivative with highly potent cytotoxicity.
CAS:
799840-96-3
Formula:
C39H56ClN3O10S
Molecular Weight:
794.4
Purity:
0.98
SMILES:
[H][C@@]12O[C@@]1(C)[C@H](CC(=O)N(C)c1cc(CC(C)=C/C=C[C@@H](OC)[C@@]3(O)C[C@]([H])(OC(=O)N3)C2(C)C)cc(OC)c1Cl)OC(=O)[C@H](C)N(C)C(=O)CCC(C)(C)S
References
1. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
2. Zhao RY, et al. Synthesis and evaluation of hydrophilic linkers for antibody-maytansinoid conjugates. J Med Chem. 2011 May 26;54(10):3606-23.