4-(tert-Butyl)-benzhydroxamic Acid
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| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
4-(tert-Butyl)-benzhydroxamic Acid is a PqsR antagonist with IC50s of 12.5 μM and 23.6 μM for E. coli and P. aeruginosa, respectively, and it reduces the production of the virulence factor pyocyanin in P. aeruginosa with an IC50 of 87.2 μM[1].
CAS:
62034-73-5
Formula:
C11H15NO2
Molecular Weight:
193.246
Purity:
0.98
SMILES:
CC(C)(C)c1ccc(cc1)C(=O)NO
References
1. Klein T, et al. Identification of small-molecule antagonists of the Pseudomonas aeruginosa transcriptionalregulator PqsR: biophysically guided hit discovery and optimization. ACS Chem Biol. 2012 Sep 21;7(9):1496-501.