Ascochlorin
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, mediates its anti-tumor effects predominantly through the suppression of STAT3 signaling cascade. Ascochlorin induces apoptosis and it has Anti-inflammatory activity[1][2][3].
CAS:
26166-39-2
Formula:
C23H29ClO4
Molecular Weight:
404.93
Pathway:
Stem Cells; JAK/STAT signaling
Purity:
0.98
SMILES:
C[C@@H]1CCC(=O)[C@H](C)[C@@]1(C)C=CC(C)=CCc1c(O)c(Cl)c(C)c(C=O)c1O
Target:
STAT
References
1. Min-Wen JC, et al. Molecular Targets of Ascochlorin and Its Derivatives for Cancer Therapy. Adv Protein Chem Struct Biol. 2017;108:199-225.
2. Lee SH, et al. Anti-Inflammatory Effect of Ascochlorin in LPS-Stimulated RAW 264.7 Macrophage Cells Is Accompanied With the Down-Regulation of iNOS, COX-2 and Proinflammatory Cytokines Through NF-?B, ERK1/2, and p38 Signaling Pathway. J Cell Biochem. 2016 Apr;117(4):978-87.
3. Dai X, et al. Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3. Mol Oncol. 2015 Apr;9(4):818-33.