BRD6989

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TargetMol
Product Code: TAR-T14778
Supplier: TargetMol
CodeSizePrice
TAR-T14778-1mg1mg£95.00
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TAR-T14778-5mg5mg£124.00
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Quantity:
TAR-T14778-1mL1 mL * 10 mM (in DMSO)£133.00
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Quantity:
TAR-T14778-10mg10mg£149.00
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Quantity:
TAR-T14778-25mg25mg£237.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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TAR-T14778-50mg50mg£367.00
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Quantity:
TAR-T14778-100mg100mg£511.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
BRD6989 is an analog of the natural product cortistatin A (dCA). Which inhibits CDK8 and upregulates IL-10. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes. BRD6989 selectively binds a complex of CDK8 with an IC50 of ~200 nM.
CAS:
642008-81-9
Formula:
C16H16N4
Molecular Weight:
264.332
Pathway:
Cell Cycle/Checkpoint; Immunology/Inflammation
Purity:
0.9882
SMILES:
CC1CCc2nc(N)c(C#N)c(-c3cccnc3)c2C1
Target:
IL Receptor; CDK; Interleukin

References

1. Johannessen L, et al. Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells. Nat Chem Biol. 2017 Oct;13(10):1102-1108