CCT367766
| Code | Size | Price |
|---|
| TAR-T14908-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
CCT367766 is the PROTAC-based pirin targeting protein degradation probe, depletes pirin protein expression at low concentration. It shows a moderate affinity for the CRBN-DDB1 complex (IC50: 490 nM). CCT367766 reveals a good affinity for the recombinant pirin and CRBN (Kds: 55 nM and 120 nM).
CAS:
2229856-58-8
Formula:
C49H48ClN7O11
Molecular Weight:
946.41
Pathway:
PROTAC
Purity:
0.98
SMILES:
Clc1ccc(NC(=O)c2ccc3OCCOc3c2)cc1NC(=O)c1ccc2nc(CN3CCN(CCOCCOCCOc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)ccc2c1
Target:
PROTACs
References
1. Chessum NEA, et al. Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).J Med Chem.?2018 Feb 8;61(3):918-933.