CL-82198

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TargetMol
Product Code: TAR-T14978
Supplier: TargetMol
CodeSizePrice
TAR-T14978-5mg5mg£102.00
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Quantity:
TAR-T14978-1mL1 mL * 10 mM (in DMSO)£105.00
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Quantity:
TAR-T14978-10mg10mg£124.00
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Quantity:
TAR-T14978-25mg25mg£195.00
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Quantity:
TAR-T14978-50mg50mg£275.00
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Quantity:
TAR-T14978-100mg100mg£389.00
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Quantity:
TAR-T14978-200mg200mg£538.00
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TAR-T14978-500mg500mg£804.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
CL-82198 is a selective inhibitor of MMP-13 and it is a pharmacologic treatment for preventing osteoarthritis (OA) progression. CL-82198 binds to the entire S1? pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs.
CAS:
307002-71-7
Formula:
C17H22N2O3
Molecular Weight:
302.374
Pathway:
Proteases/Proteasome
Purity:
0.9591
SMILES:
O=C(NCCCCN1CCOCC1)c1cc2ccccc2o1
Target:
MMP

References

1. Rath T et al. Matrix metalloproteinase-13 is regulated by toll-like receptor-9 in colorectal cancer cells and mediates cellular migration. Oncol Lett. 2011 May;2(3):483-488. 2. George J, et al. MMP-13 deletion decreases profibrogenic molecules and attenuates N-nitrosodimethylamine-induced liver injury and fibrosis in mice. J Cell Mol Med. 2017 Dec;21(12):3821-3835. 3. Wohlauer M et al. Nebulized hypertonic saline attenuates acute lung injury following trauma and hemorrhagic shock via inhibition of matrix metalloproteinase-13. Crit Care Med. 2012 Sep;40(9):2647-53. 4. Wang M,et al. MMP13 is a critical target gene during the progression of osteoarthritis. Arthritis Res Ther. 2013 Jan 8;15(1):R5.