MAK683

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TargetMol
Product Code: TAR-T15201
Supplier: TargetMol
CodeSizePrice
TAR-T15201-1mg1mg£109.00
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Quantity:
TAR-T15201-1mL1 mL * 10 mM (in DMSO)£148.00
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Quantity:
TAR-T15201-5mg5mg£158.00
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Quantity:
TAR-T15201-10mg10mg£230.00
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Quantity:
TAR-T15201-25mg25mg£418.00
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Quantity:
TAR-T15201-50mg50mg£583.00
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Quantity:
TAR-T15201-100mg100mg£787.00
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TAR-T15201-500mg500mg£1,556.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay).
CAS:
1951408-58-4
Formula:
C20H17FN6O
Molecular Weight:
376.395
Pathway:
Chromatin/Epigenetic
Purity:
0.9992
SMILES:
Cc1ncccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Target:
DNA Methyltransferase; Histone Methyltransferase

References

1. Chan, Ho Man, et al. TRIAZOLOPYRIMIDINE COMPOUNDS AND USES THEREOF. US20160176882 A1. 2. Huang D, et al. Binding Modes of Small-Molecule Inhibitors to the EED Pocket of PRC2. Chemphyschem. 2020 Feb 4;21(3):263-271.