K-252b
| Code | Size | Price |
|---|
| TAR-T15637-5mg | 5mg | £1,177.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
K-252b is an indolocarbazole isolated from the actinomycete Nocardiopsis and is a PKC inhibitor. K-252b can be used to inhibit extracellular kinases of cells in culture because it can?t pass through the cell membrane freely.
CAS:
99570-78-2
Formula:
C26H19N3O5
Molecular Weight:
453.454
Pathway:
Cytoskeletal Signaling; Chromatin/Epigenetic
Purity:
0.98
SMILES:
[H][C@]12C[C@](O)(C(O)=O)[C@](C)(O1)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Target:
PKC
References
1. Yasuzawa, T., et al. The structures of the novel protein kinase C inhibitors K-252a, b, c AND d Journal of Antibiotics 39(8), 1072-1078 (1986).
2. Plomp, J.J., et al. Involvement of protein kinases in the upregulation of acetylcholine release at endplates of ?-bungarotoxin-treated rats Journal of Physiology 493, 175-186 (1996).
3. Zhu, X., et al. Evidence of ectokinase-mediated phosphorylation of osteopontin and bone sialoprotein by osteoblasts during bone formation in vitro Biochemistry Journal 323, 637-643 (1997).