Ribociclib succinate

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TargetMol
Product Code: TAR-T15732
Supplier: TargetMol
CodeSizePrice
TAR-T15732-2mg2mg£95.00
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TAR-T15732-5mg5mg£108.00
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TAR-T15732-1mL1 mL * 10 mM (in DMSO)£117.00
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Quantity:
TAR-T15732-10mg10mg£124.00
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Quantity:
TAR-T15732-25mg25mg£149.00
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Quantity:
TAR-T15732-50mg50mg£164.00
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Quantity:
TAR-T15732-100mg100mg£213.00
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TAR-T15732-200mg200mg£300.00
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Quantity:
TAR-T15732-500mg500mg£479.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Ribociclib succinate is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively). It also is over 1,000-fold less potent against the cyclin B/CDK1 complex.
CAS:
1374639-75-4
Formula:
C27H36N8O5
Molecular Weight:
552.636
Pathway:
Cell Cycle/Checkpoint
Purity:
0.9957
SMILES:
OC(=O)CCC(O)=O.CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n1C1CCCC1
Target:
CDK

References

1. VanArsdale T, et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1;21(13):2905-10. 2. Rader J, et al. Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma. Clin Cancer Res. 2013 Nov 15;19(22):6173-82.