SRT 2183

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TargetMol
Product Code: TAR-T16932
Supplier: TargetMol
CodeSizePrice
TAR-T16932-1mg1mg£107.00
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TAR-T16932-2mg2mg£124.00
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TAR-T16932-5mg5mg£158.00
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TAR-T16932-1mL1 mL * 10 mM (in DMSO)£161.00
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TAR-T16932-10mg10mg£205.00
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TAR-T16932-25mg25mg£309.00
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TAR-T16932-50mg50mg£434.00
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TAR-T16932-100mg100mg£597.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).
CAS:
1001908-89-9
Formula:
C27H24N4O2S
Molecular Weight:
468.58
Pathway:
DNA Damage/DNA Repair; Chromatin/Epigenetic; Apoptosis
Purity:
1
SMILES:
O[C@@H]1CCN(Cc2csc3nc(cn23)-c2ccccc2NC(=O)c2ccc3ccccc3c2)C1
Target:
Apoptosis; Sirtuin

References

1. Scuto A, et al. SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-?B/STAT3 complex to its promoter in malignant lymphoid cells. Cell Death Dis. 2013 May; 4(5): e635. 2. Milne JC, et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29; 450(7170): 712?716.