TargetMol

Bufalin

Product Code:
 
TAR-T1719
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1719-5mg5mg£115.00
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TAR-T1719-1mL1 mL * 10 mM (in DMSO)£119.00
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TAR-T1719-10mg10mg£135.00
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TAR-T1719-25mg25mg£177.00
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TAR-T1719-50mg50mg£229.00
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Further Information

Bioactivity:
Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potential cardiotonic and antineoplastic activity. Although the mechanism of action of bufalin is still under investigation, this agent is a specific Na+/K+-ATPase inhibitor and can induce apoptosis in Y cell lines through the activation of the transcription factor AP-1 via a mitogen activated protein kinase (MAPK) pathway.
CAS:
465-21-4
Formula:
C24H34O4
Molecular Weight:
386.532
Pathway:
Membrane transporter/Ion channel
Purity:
0.9836
SMILES:
[H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@H](CC[C@]34O)c3ccc(=O)oc3)[C@@]1(C)CC[C@H](O)C2
Target:
ATPase

References

1. Chen YY, et al. Environ Toxicol. 2015 Jan;30(1):74-82. 2. Chen F, Zhu L, Hu J, et al. Bufalin attenuates triple?negative breast cancer cell stemness by inhibiting the expression of SOX2/OCT4[J]. Oncology letters. 2020, 20(5): 1-1.