Afatinib Dimaleate
Code | Size | Price |
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TAR-T1773-5mg | 5mg | £98.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1773-10mg | 10mg | £114.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1773-1mL | 1 mL * 10 mM (in DMSO) | £119.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1773-25mg | 25mg | £134.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1773-100mg | 100mg | £186.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1773-200mg | 200mg | £230.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Afatinib is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with antineoplastic activity.
CAS:
850140-73-7
Formula:
C32H33ClFN5O11
Molecular Weight:
718.09
Pathway:
Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors; Autophagy
Purity:
0.9966
SMILES:
OC(=O)C=C/C(O)=O.OC(=O)C=C/C(O)=O.CN(C)CC=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1
Target:
EGFR; HER; Autophagy
References
1. D Li, et al. Oncogene. 2008, 27(34):4702-4711.
2. Wang XK, et al. Cancer Res. 2014, 74(16):4431-4445.
3. Gurtner K, et al. Radiat Oncol. 2014, 9:261.
4. Schwab CL, et al. Br J Cancer. 2014, 111(9):1750-1756.
5. Janjiqian YY, et al. J Nucl Med. 2013, 54(6):936-943.
6. Li C, Sun Y D, Yu G Y, et al. Integrated Omics of Metastatic Colorectal Cancer[J]. Cancer Cell. 2020, 38(5): 734-747. e9