Plerixafor

TargetMol
Product Code: TAR-T1776
Supplier: TargetMol
CodeSizePrice
TAR-T1776-5mg5mg£104.00
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TAR-T1776-10mg10mg£121.00
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Quantity:
TAR-T1776-25mg25mg£161.00
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Quantity:
TAR-T1776-50mg50mg£214.00
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Quantity:
TAR-T1776-100mg100mg£330.00
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Quantity:
TAR-T1776-200mg200mg£483.00
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TAR-T1776-500mg500mg£728.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Further Information

Bioactivity:
Plerixafor, a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.
CAS:
110078-46-1
Formula:
C28H54N8
Molecular Weight:
502.796
Pathway:
GPCR/G Protein; Microbiology/Virology; Proteases/Proteasome; Immunology/Inflammation; Autophagy
Purity:
0.9917
SMILES:
C(N1CCCNCCNCCCNCC1)c1ccc(CN2CCCNCCNCCCNCC2)cc1
Target:
Virus Protease; HIV Protease; CXCR

References

1. Zabel BA, et al. J Immunol. 2009, 183(5), 3204-3211. 2. Fricker SP, et al. Biochem Pharmacol. 2006, 72(5), 588-596. 3. Nishimura Y, et al. J Invest Dermatol. 2012, 132(3 Pt 1), 711-720. 4. Kumar S, et al. Bone. 2012, 50(4), 12012-12018. 5. Wei He, et al. Targeting CXC motif chemokine receptor 4 inhibits the proliferation, migration and angiogenesis of lung cancer cells. Oncol Lett. 2018 Sep;16(3):3976-3982. 6. Mercurio L, et al. Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model. J Exp Clin Cancer Res. 2016 Mar 25;35:55. 7. Yang J, et al. Continuous AMD3100 Treatment Worsens Renal Fibrosis through Regulation of Bone Marrow Derived Pro-Angiogenic Cells Homing and T-Cell-Related Inflammation. PLoS One. 2016 Feb 22;11(2):e0149926. 8. He G, et al. SDF-1 in Mammary Fibroblasts of Bovine with Mastitis Induces EMT and Inflammatory Response of Epithelial Cells. Int J Biol Sci. 2017 May 5;13(5):604-614. 9. Dong L, Shen S, Chen W, et al. Discovery of Novel Inhibitors Targeting Human O-GlcNAcase: Docking-Based Virtual Screening, Biological Evaluation, Structural Modification, and Molecular Dynamics Simulation[J]. Journal of chemical information and modeling. 2019, 59(10): 4374-4382.