BX795

Contact us
TargetMol
Product Code: TAR-T1830
Supplier: TargetMol
CodeSizePrice
TAR-T1830-5mg5mg£114.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T1830-1mL1 mL * 10 mM (in DMSO)£136.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T1830-10mg10mg£149.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T1830-25mg25mg£247.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T1830-50mg50mg£360.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T1830-100mg100mg£504.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T1830-200mg200mg£696.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T1830-500mg500mg£1,018.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

1 / 1
❮❯

Documents

Further Information

Bioactivity:
BX795 is an effective and selective PDK1 inhibitor (IC50: 6 nM), and its selectivity is 140- and 1600-fold for PDK1 over PKA and PKC in cell-free assays, respectively. Meanwhile, the selectivity for PDK1 is 100-fold than GSK3β.
CAS:
702675-74-9
Formula:
C23H26IN7O2S
Molecular Weight:
591.47
Pathway:
Autophagy; NF-κb; Tyrosine Kinase/Adaptors; PI3K/Akt/mTOR signaling; Cell Cycle/Checkpoint
Purity:
0.9957
SMILES:
Ic1cnc(Nc2cccc(NC(=O)N3CCCC3)c2)nc1NCCCNC(=O)c1cccs1
Target:
IκB/IKK; Chk; CDK; c-Kit; PDK; Autophagy

References

1. Feldman RI, et al. J Biol Chem. 2005, 280(20), 19867-119874. 2. Clark K, et al. J Biol Chem. 2009, 284(21), 14136-14146. 3. Dangelmaier C, et al. Thromb Haemost. 2013,111(4).