Kobe0065

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TargetMol
Product Code: TAR-T1876
Supplier: TargetMol
CodeSizePrice
TAR-T1876-5mg5mg£102.00
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TAR-T1876-10mg10mg£116.00
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TAR-T1876-25mg25mg£149.00
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TAR-T1876-50mg50mg£185.00
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TAR-T1876-100mg100mg£258.00
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TAR-T1876-200mg200mg£381.00
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TAR-T1876-500mg500mg£589.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
Kobe0065 is a novel and effective small-molecule compound inhibiting Ras?Raf interaction by SBDD; shows potent activity to competitively inhibit the binding of H-Ras?GTP to c-Raf-1 RBD with a Ki value of 46 ? 13 μM.
CAS:
436133-68-5
Formula:
C15H11ClF3N5O4S
Molecular Weight:
449.79
Pathway:
GPCR/G Protein; MAPK; Apoptosis
Purity:
0.9976
SMILES:
Cc1ccc(NC(=S)NNc2c(cc(cc2[N+]([O-])=O)C(F)(F)F)[N+]([O-])=O)cc1Cl
Target:
Apoptosis; Raf; Ras

References

1. Shima F, et al. Proc Natl Acad Sci U S A. 2013, 110(20):8182-7.