TargetMol

XAV-939

Product Code:
 
TAR-T1878
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1878-5mg5mg£109.00
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TAR-T1878-1mL1 mL * 10 mM (in DMSO)£114.00
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TAR-T1878-10mg10mg£118.00
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TAR-T1878-25mg25mg£160.00
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TAR-T1878-50mg50mg£214.00
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TAR-T1878-100mg100mg£292.00
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Quantity:
TAR-T1878-200mg200mg£464.00
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Further Information

Bioactivity:
XAV-939 shows the selective inhibition against Wnt/β-catenin-mediated transcription by tankyrase1/2 inhibition (IC50: 11/4 nM in cell-free assays).
CAS:
284028-89-3
Formula:
C14H11F3N2OS
Molecular Weight:
312.31
Pathway:
Cytoskeletal Signaling; Stem Cells; DNA Damage/DNA Repair; Chromatin/Epigenetic
Purity:
0.989
SMILES:
Oc1nc(nc2CCSCc12)-c1ccc(cc1)C(F)(F)F
Target:
PARP; Wnt/beta-catenin

References

1. Dregalla RC, et al. Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs. Aging (Albany NY). 2010 Oct;2(10):691-708. 2. Huang SM, et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature. 2009 Oct 1;461(7264):614-620. 3. Bai J, et al. Epigenetic downregulation of SFRP4 contributes to epidermal hyperplasia in psoriasis. J Immunol. 2015 May 1;194(9):4185-98. doi: 10.4049/jimmunol.1403196. Epub 2015 Mar 30. 4. Geng W, Guo X, Zhang L, et al. Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/?-catenin signaling pathway[J]. Biomedicine & Pharmacotherapy. 2018 Nov;107:484-494.