AR-A014418
Code | Size | Price |
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TAR-T1881-5mg | 5mg | £107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1881-1mL | 1 mL * 10 mM (in DMSO) | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1881-10mg | 10mg | £113.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1881-25mg | 25mg | £144.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1881-50mg | 50mg | £204.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1881-100mg | 100mg | £302.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1881-200mg | 200mg | £371.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
AR-A014418 is an ATP-competitive, and selective GSK3β inhibitor.
CAS:
487021-52-3
Formula:
C12H12N4O4S
Molecular Weight:
308.31
Pathway:
PI3K/Akt/mTOR signaling; Stem Cells
Purity:
0.9994
SMILES:
COc1ccc(CNC(=O)Nc2ncc(s2)[N+]([O-])=O)cc1
Target:
GSK-3
References
1. Bhat R, et al. J Biol Chem. 2003, 278(46), 45937-45945.
2. Carter YM, et al. Cancer Biol Ther. 2014, 15(5).
3. Koh SH, et al. Exp Neurol. 2007, 205(2), 336-346.
4. Martins DF, et al. J Pain. 2011, 12(3), 315-322.
5. Mai C L, Wei X, Gui W S, et al. Differential regulation of GSK-3? in spinal dorsal horn and in hippocampus mediated by interleukin-1beta contributes to pain hypersensitivity and memory deficits following peripheral nerve injury[J]. Molecular pain. 2019, 15: 1744806919826789.
6. Tian J, Li X, Zhao L, et al. Glycyrrhizic Acid Promotes Neural Repair by Directly Driving Functional Remyelination[J]. Food & Function. 2019.
7. Zhang Y, Zhang J, Wang E, et al. Microcystin-Leucine-Arginine Induces Tau Pathology Through B? Degradation via Protein Phosphatase 2A Demethylation and Associated Glycogen Synthase Kinase-3? Phosphorylation. Toxicological Sciences. 2018, 162(2): 475-487.
8. Zhang Y, Zhang J, Wang E, et al. Microcystin-LR induces tau pathology through B? degradation via PP2A demethylation and associated GSK-3? phosphorylation[J]. Toxicological Sciences. 2018 Apr 1;162(2):475-487.