SGI-1027

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TargetMol
Product Code: TAR-T1904
Supplier: TargetMol
CodeSizePrice
TAR-T1904-5mg5mg£113.00
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TAR-T1904-1mL1 mL * 10 mM (in DMSO)£125.00
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TAR-T1904-10mg10mg£147.00
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TAR-T1904-25mg25mg£204.00
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TAR-T1904-50mg50mg£321.00
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TAR-T1904-100mg100mg£466.00
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TAR-T1904-500mg500mg£946.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
SGI-1027 is an effective and selective inhibitor of DNA methyltransferase (DNMT). The IC50 of SGI-1027 against DNMT1, DNMT3A, and DNMT3B are 6, 8, 7.5 μM, respectively.
CAS:
1020149-73-8
Formula:
C27H23N7O
Molecular Weight:
461.529
Pathway:
Apoptosis; Chromatin/Epigenetic
Purity:
0.9945
SMILES:
Cc1cc(Nc2ccc(NC(=O)c3ccc(Nc4ccnc5ccccc45)cc3)cc2)nc(N)n1
Target:
Apoptosis; DNA Methyltransferase

References

1. Datta J, et al. Cancer Res. 2009, 69(10), 4277-4285. 2. Garc?a-Dom?nguez P, et al. Bioorg Med Chem Lett. 2013, 23(6):1631-5.