LDN193189

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TargetMol
Product Code: TAR-T1935
Supplier: TargetMol
CodeSizePrice
TAR-T1935-2mg2mg£103.00
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TAR-T1935-5mg5mg£124.00
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TAR-T1935-10mg10mg£140.00
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TAR-T1935-25mg25mg£189.00
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TAR-T1935-50mg50mg£261.00
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TAR-T1935-100mg100mg£354.00
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TAR-T1935-200mg200mg£491.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
LDN193189 (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8/0.8/5.3/16.7 nM for ALK1/2/3/6).
CAS:
1062368-24-4
Formula:
C25H22N6
Molecular Weight:
406.493
Pathway:
Stem Cells; Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.9911
SMILES:
C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12
Target:
ALK; TGF-beta/Smad

References

1. Yu PB, et al. BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med, 2008, 14(12), 1363-1369. 2. Derwall M, et al. Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):613-22. 3. Lee YC, et al. BMP4 promotes prostate tumor growth in bone through osteogenesis. Cancer Res, 2011, 71(15), 5194-5203.