TargetMol

BS-181

Product Code:
 
TAR-T1947
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1947-5mg5mg£141.00
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Quantity:
TAR-T1947-1mL1 mL * 10 mM (in DMSO)£149.00
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TAR-T1947-10mg10mg£191.00
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TAR-T1947-50mg50mg£470.00
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This product comes from: United States.
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Further Information

Bioactivity:
BS-181 is a highly selective CDK7 inhibitor (IC50: 21 nM); >40-fold selective for CDK7 than CDK1/2/4/5/6/9.
CAS:
1092443-52-1
Formula:
C22H32N6
Molecular Weight:
380.54
Pathway:
Apoptosis; Cell Cycle/Checkpoint
Purity:
0.98
SMILES:
CC(C)c1cnn2c(NCc3ccccc3)cc(NCCCCCCN)nc12
Target:
Apoptosis; CDK

References

1. Cancer Res. 2009 Aug 1;69(15):6208-15. doi: 10.1158/0008-5472.CAN-09-0301. Epub 2009 Jul 28. 2. Wang BY, et al. Selective CDK7 inhibition with BS-181 suppresses cell proliferation and induces cell cycle arrest and apoptosis in gastric cancer. Drug Des Devel Ther. 2016 Mar 16;10:1181-9.