Lobucavir
| Code | Size | Price |
|---|
| TAR-T19632-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Lobucavir inhibits the replication of the HIV virus in T cells, monocytes & macrophages in vitro by inhibiting DNA polymerase and viral DNA synthesis.
CAS:
126062-18-8
Formula:
C11H15N5O3
Molecular Weight:
265.273
Purity:
0.98
SMILES:
Nc1nc2n(cnc2c(=O)[nH]1)[C@H]1C[C@@H](CO)[C@@H]1CO
References
1. Woicke J, Durham SK, Mense MG. Lobucavir-induced proliferative changes in mice. Exp Toxicol Pathol. 2007 Nov;59(3-4):197-204. Epub 2007 Oct 17. PubMed PMID: 17942294.
2. Yang Z, Manitpisitkul P, Sawchuk RJ. In situ studies of regional absorption of lobucavir and ganciclovir from rabbit intestine and predictions of dose-limited absorption and associated variability in humans. J Pharm Sci. 2006 Oct;95(10):2276-92. PubMed PMID: 16883564.
3. Genovesi EV, Lamb L, Medina I, Taylor D, Seifer M, Innaimo S, Colonno RJ, Clark JM. Antiviral efficacy of lobucavir (BMS-180194), a cyclobutyl-guanosine nucleoside analogue, in the woodchuck (Marmota monax) model of chronic hepatitis B virus (HBV) infection. Antiviral Res. 2000 Dec;48(3):197-203. PubMed PMID: 11164506.
4. Hanson RL, Shi Z, Brzozowski DB, Banerjee A, Kissick TP, Singh J, Pullockaran AJ, North JT, Fan J, Howell J, Durand SC, Montana MA, Kronenthal DR, Mueller RH, Patel RN. Regioselective enzymatic aminoacylation of lobucavir to give an intermediate for lobucavir prodrug. Bioorg Med Chem. 2000 Dec;8(12):2681-7. PubMed PMID: 11131158.